Server has been running without changes.
Updated to Release 8.0.5_GA_5839.RHEL6_64_20130910123908 RHEL6_64 FOSS edition.
after problem started, still the same.
Server seems to be running fine, but some users complain that their ZWC is bahaving starnge, showing mails in inbox (10) but no mail visible.
Below is some more info, I searched and tried everything I could find relating to this, but no luck yet.
Any other pointers I might try?

zmfixperms --extended
restarted zimbra
checked /etc/sudoers
/opt/zimbra/postfix/sbin/postqueue did not have Set-GID set, set now, restarted, not change.

[zimbra@mail root]$ postqueue -p
postqueue: fatal: Connect to the Postfix showq service: Permission denied


[root@mail ~]# ls -ld /opt/zimbra/postfix/sbin/postqueue /opt/zimbra/data/postfix/spool/public/* /opt/zimbra/data/postfix/spool/maildrop
drwx-wx---. 2 postfix postdrop 12288 Oct 4 12:53 /opt/zimbra/data/postfix/spool/maildrop
srw-rw-rw- 1 postfix postfix 0 Oct 4 12:41 /opt/zimbra/data/postfix/spool/public/cleanup
srw-rw-rw- 1 postfix postfix 0 Oct 4 12:41 /opt/zimbra/data/postfix/spool/public/flush
srw-rw-rw- 1 postfix postfix 0 Oct 4 12:41 /opt/zimbra/data/postfix/spool/public/pickup
srw-rw-rw- 1 postfix postfix 0 Oct 4 12:41 /opt/zimbra/data/postfix/spool/public/qmgr
srw-rw-rw- 1 postfix postfix 0 Oct 4 12:41 /opt/zimbra/data/postfix/spool/public/showq
-rwxr-xr-x 1 root postdrop 892368 Jul 6 02:14 /opt/zimbra/postfix/sbin/postqueue


Don't know why it's complaining about starting running everything in root?
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmamavisdctl: (Cannot run program "/opt/zimbra/bin/zmamavisdctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmclamdctl: (Cannot run program "/opt/zimbra/bin/zmclamdctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/ldap: (Cannot run program "/opt/zimbra/bin/ldap" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmloggerctl: (Cannot run program "/opt/zimbra/bin/zmloggerctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmstorectl: (Cannot run program "/opt/zimbra/bin/zmstorectl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmmailboxdctl: (Cannot run program "/opt/zimbra/bin/zmmailboxdctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmmtactl: (Cannot run program "/opt/zimbra/bin/zmmtactl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmopendkimctl: (Cannot run program "/opt/zimbra/bin/zmopendkimctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmsaslauthdctl: (Cannot run program "/opt/zimbra/bin/zmsaslauthdctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmswatchctl: (Cannot run program "/opt/zimbra/bin/zmswatchctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmspellctl: (Cannot run program "/opt/zimbra/bin/zmspellctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmstatctl: (Cannot run program "/opt/zimbra/bin/zmstatctl" (in directory "/root"): error=13, Permission denied)
Oct 4 13:20:26 mail zmconfigd[32185]: Exception in bin/zmclamdctl: (Cannot run program "/opt/zimbra/bin/zmclamdctl" (in directory "/root"): error=13, Permission denied)

Oct 4 13:20:30 mail postfix/postqueue[4288]: fatal: Connect to the Postfix showq service: Permission denied