I just enabled antivirus and antispam. But now have a problem routing my email. My MTA is trying to route mail to, but my mail store is not on the localhost.

Nov 9 13:56:00 zimbra postfix/smtp[25176]: BB44050F313: to=, relay=[], delay=0, status=deferred (lost connection with[] while sending RCPT TO)

I need it to relay to 198.x.x.220 not How do I make this change? Thank you.