I just enabled antivirus and antispam. But now have a problem routing my email. My MTA is trying to route mail to 127.0.0.1, but my mail store is not on the localhost.

Nov 9 13:56:00 zimbra postfix/smtp[25176]: BB44050F313: to=, relay=127.0.0.1[127.0.0.1], delay=0, status=deferred (lost connection with 127.0.0.1[127.0.0.1] while sending RCPT TO)

I need it to relay to 198.x.x.220 not 127.0.0.1. How do I make this change? Thank you.